📊 Publicly benchmarked · 1,129 stars · 97 skills · 50 contributors · 4,723 tests

The first bioinformatics-native
AI agent skill library

ClawBio is where biological AI gets its skills: a curated, reproducible, open repository any agent can call.

        $ pip install clawbio
      

🚀 New in v0.7.0: the library installs as a Claude Code plugin or plain Agent Skills, and the headline skills write SHA-256 reproducibility bundles.

⭐ View on GitHub 📊 Leaderboard · 161/182 🧬 Submit a Skill 🤖 Try RoboTerri

bioinformaticsgenomicsreproducibilitypopulation-geneticsequityai-agentslocal-firstopenclaw

v0.7.0 · Agent Skills

Genomics skills, in your editor

Every ClawBio skill is a plain Agent Skills folder: a SKILL.md contract, the script that executes it, demo data and tests. Claude Code installs the whole library as a plugin. Cursor, VS Code, Codex, Zed and any other editor that reads Agent Skills load the folders from ~/.agents/skills/. The runnable skills execute on your machine and hand back the report, the structured result, and a commands.sh with SHA-256 checksums, so the analysis can be replayed without the agent that produced it.

            > /plugin marketplace add ClawBio/ClawBio
          

Then /plugin install clawbio. Other editors: copy or symlink the skill folders you need into ~/.agents/skills/.

✅ 97 skills, 91 with a deterministic CLI entry point
🔒 Demo data included, your files only when you pass them
🏠 Local-first. No server, no hosted endpoint, by design

# Claude Code
/plugin marketplace add ClawBio/ClawBio
/plugin install clawbio

# Cursor, VS Code, Codex, Zed: Agent Skills
git clone https://github.com/ClawBio/ClawBio
cp -r ClawBio/skills/pharmgx-reporter ~/.agents/skills/

# Python, any language
pip install clawbio
clawbio run pharmgx --demo

The MCP server introduced in v0.6.0 is deprecated as of v0.7.0 and will be removed in v0.8.0. Existing clawbio mcp configurations keep working until then and print a notice on start. Why, and how to migrate.

🚀 What is new in v0.7.0 🏷️ Release notes 📄 MCP migration guide

The Problem

Reproducing bioinformatics analyses is broken

# Without ClawBio
$ git clone repo && cd repo
# Wrong Python version...
# Reference data link is dead...
# Paths hardcoded to /home/jsmith/data/
# Email first author. Wait 3 weeks.
# Give up.

✗ Dependency hell & broken environments
✗ Dead links to reference data
✗ Hardcoded paths & missing configs
✗ AI hallucinates star alleles & outdated guidelines
✗ No audit trail, no checksums

# With ClawBio
$ python skills/multiqc-reporter/multiqc_reporter.py --demo --output /tmp/multiqc_demo

✓ Demo report regenerated.
✓ Replay command saved alongside outputs.
✓ Checksums available for verification.

# Or with natural language:
$ openclaw "Profile my pharmacogenes"

Many skills write a reproducibility/ bundle with replay commands, environment metadata, and output checksums. Exact files vary by skill, and some replays still require local tools or original inputs.

Why ClawBio

Domain expertise, frozen into code

ChatGPT and Claude are smart generalists. ClawBio skills are domain experts' proven pipelines — executed correctly every time.

🏠

Local-first by default

Your genome is analysed on your machine. Skills that transmit data to external services are clearly labelled and run only when you invoke them.

🔁

Reproducible

Many skills export replay bundles with commands, environment metadata, and output checksums so runs can be rechecked without the original agent session.

🧩

Modular

Each skill is a self-contained directory (SKILL.md + Python scripts) that plugs into the orchestrator — or runs standalone.

⚖️

MIT Licensed

Open-source, free, community-driven. Clone it, run it, build a skill, submit a PR.

🌍

Equity-aware

Built-in support for underrepresented populations. HEIM diversity metrics baked into the roadmap.

🎯

Benchmark Validated

Public scientific-correctness leaderboard: 161/182 tests passing (88.5%) as of 26 Jul 2026, across 10 of 95 skills, every failure tagged. The suite currently reports an overall FAIL: nutrigx-advisor regressed from 10/10 to 0/10. AD ground truth (34 genes, 3 evidence tiers), mock API server for offline CI, swappable fine-mapping (ABF vs SuSiE), benchmark scorer with precision/recall/F1. View leaderboard · DOI

🦞

Built on OpenClaw

Powered by OpenClaw, the open agent platform that routes natural language to the right specialist skill. ClawBio is the bioinformatics catalogue any OpenClaw-compatible agent can call.

🔌

Claude Code Plugin

Install with two commands: /plugin marketplace add ClawBio/ClawBio then /plugin install clawbio. All skills instantly available.

Skills Library

97 skills · 91 with runnable demo data · 4,723 tests · 161 / 182 publicly benchmarked passing

Each skill includes demo data so you can try it immediately without your own files.

💊 PharmGx Reporter

Pharmacogenomic report from 23andMe/AncestryDNA: 12 genes, 31 SNPs, 51 drugs, CPIC guidelines.

MVP

🥦 NutriGx Advisor

Personalised nutrition report from consumer genetic data: MTHFR, folate, vitamin D, caffeine, lactose, omega-3, and more.

MVP

🔍 GWAS Lookup

Federated variant lookup across 9 genomic databases: GWAS Catalog, Open Targets, PheWeb (UKB, FinnGen, BBJ), GTEx, eQTL Catalogue, and more.

MVP

📊 GWAS Polygenic Risk

Calculate polygenic risk scores from DTC genetic data using curated PGS Catalog scores across 6 traits.

MVP

⚖️ Equity Scorer

Compute HEIM diversity and equity metrics from VCF or ancestry data: heterozygosity, FST, and population representation scores.

MVP

+ 92 more skills on GitHub · see which ones are publicly benchmarked →

In Production

ClawBio skills, running in conversation

ClawBio skills aren't just CLI tools — they power live AI agents that talk to real users every day.

RoboTerri

Telegram AI Agent

A bioinformatics intelligence agent on Telegram — inspired by Professor Teresa K. Attwood, a pioneer of bioinformatics education and research. Run pharmacogenomics reports from your own genetic data. Snap a photo of your medication, get personalised dosage guidance. Local-first, with reproducibility support where the underlying skill writes a replay bundle.

PharmGx Reporter Drug Photo Lookup NutriGx Advisor Genome Compare Equity Scorer Metagenomics GWAS Lookup scRNA Orchestrator

Community

Wanted: skills from the community

If you work with genomics, proteomics, metabolomics, imaging, or clinical data — wrap your pipeline as a skill.

claw-gwas

PLINK/REGENIE automation — Statistical genetics

claw-acmg

Clinical variant classification — Clinical genomics

claw-pathway

GO/KEGG enrichment — Functional genomics

claw-phylogenetics

IQ-TREE/RAxML automation — Evolutionary biology

claw-spatial

Visium/MERFISH — Spatial transcriptomics

claw-long-reads

ONT/PacBio QC and assembly — Long-read sequencing

Your skill here

🎮 Join the Discord 💬 Join the Telegram 📖 Read the contribution guide

Repo	OpenClaw	Stars	Forks	Skills
ClawBio	✓	1,129	262	97
OpenClaw-Medical-Skills	✓	1,037	123	869
bioSkills	✓	331	52	425
LabClaw	✓	317	54	211
claude-scientific-skills	~	14.5k	1,585	250
Biomni	—	2,826	508	314

Recent Updates

Latest from the community

📄

Document test verification results and clarify optional dependencies. Test verification results are now documented alongside each skill, and optional dependency declarations have been clarified to reduce confusion for contributors setting up new environments. Contributed by @chronicgiardia.

PR #385 · merged · 10 September 2026

🛠️

Feat(wgs-prs): add reproducibility bundle. The WGS PRS bridge now writes a reproducibility bundle alongside its output, including the replay command, environment metadata, and SHA-256 checksums for all generated files. Contributed by @krudo-taco.

PR #390 · merged · 10 September 2026

🐛

Fix(wgs-prs): embed the gwas-prs report in bridge output. The WGS PRS bridge now correctly embeds the full gwas-prs report in its output bundle rather than referencing an external path, ensuring the complete result is self-contained. Contributed by @krudo-taco.

PR #409 · merged · 10 September 2026

🧬

New skill: claw-amplicon-qc v0.2.2. 16S/18S rRNA amplicon preprocessing from raw paired-end FASTQs: adapter trimming, primer removal, quality filtering, DADA2 denoising, and a per-sample QC report. Contributed by @deathwhisper47.

PR #329 · merged · 9 September 2026

📊

Feat(benchmark): add offline atlas split preflight. The benchmark suite now includes a preflight check that validates the offline atlas split before scoring begins, preventing silent miscounts on partially-downloaded lineage databases. Contributed by @manuelcorpas.

PR #397 · merged · 8 September 2026

📄

Docs: require the reproducibility bundle in CLAUDE.md and AGENTS.md. Updated the agent instructions to make the reproducibility bundle a mandatory output for all runnable skills, ensuring consistent replay artefacts across the catalogue. Contributed by @camlloyd.

PR #373 · merged · 8 September 2026

📄

Docs: align tutorial SKILL.md with current skill-lint schema. The tutorial skill template now matches the field names and section order enforced by the skill-lint CI check, so new contributors get a passing scaffold out of the box. Contributed by @krudo-taco.

PR #369 · merged · 8 September 2026

⚙️

CI: move pinned actions to node24 runtimes. Updated all pinned GitHub Actions to run on Node.js 24 runtimes, keeping CI dependencies current and removing deprecation warnings from older runtimes. Contributed by @camlloyd.

PR #401 · merged · 7 September 2026

⚙️

CI: let scientific-audit start without waiting for test. Removed the blocking dependency so the scientific-audit CI job starts immediately, reducing total pipeline wall time. Contributed by @camlloyd.

PR #402 · merged · 7 September 2026

⚡

Perf(genome-compare): share parsed genomes and the demo run across tests. Parsed genome objects are now shared across the test suite rather than re-read per test, cutting genome-compare CI time significantly. Contributed by @camlloyd.

PR #404 · merged · 7 September 2026

View all merged pull requests on GitHub →

Get started in 30 seconds

Install with pip, conda, as a Claude Code plugin, or as Agent Skills in any editor that reads them. Every skill includes demo data.

        # Option 1: pip (recommended)

        pip install clawbio

        clawbio run pharmgx --demo

        # Option 2: conda

        conda install -c bioconda clawbio

        # Option 3: Claude Code plugin

        /plugin marketplace add ClawBio/ClawBio

        /plugin install clawbio

        # Option 4: Agent Skills (Cursor, VS Code, Codex, Zed)

        git clone https://github.com/ClawBio/ClawBio

        cp -r ClawBio/skills/pharmgx-reporter ~/.agents/skills/

⭐ Star on GitHub 🤖 Try RoboTerri 📄 Documentation

The first bioinformatics-nativeAI agent skill library

Genomics skills, in your editor

Get started in 30 seconds

The first bioinformatics-native
AI agent skill library