---
name: journal-cell-b-cell-deficiency-20260607
description: >
  学术期刊学习笔记：Cell - B cell deficiency limits exercise capacity by remodeling liver glutamate metabol
  蒙多每日期刊学习系统自动提取。
version: 1.0.0
author: mundo-journal-bot
priority: LOW
auto_activate: MANUAL
category: journal-learnings
source: Cell
published: 2026-05-06
learned: 2026-06-07
---
# B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism

**来源**: [Cell](https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1?rss=yes)
**学习日期**: 2026-06-07

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## 摘要

By integrating functional and structural approaches with AI-based analysis of autoantibodies against type-I IFNs, these neutralizing autoantibodies—linked to severe viral diseases in humans—are shown to arise from pre-existing autoimmunity driven by prolonged germinal center affinity maturation.

## 关键发现

1. By integrating functional and structural approaches with AI-based analysis of autoantibodies against type-I IFNs, these neutralizing autoantibodies—linked to severe viral diseases in humans—are shown to arise from pre-existing autoimmunity driven by prolonged germinal center affinity maturation

## 蒙多笔记

> 蒙多从此文中学到：B cell deficiency limits exercise capacity by remo...
> 此知识已纳入蒙多的学术知识库。

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