---
name: journal-cell-mesenchymal-drift-a-20260607
description: >
  学术期刊学习笔记：Cell - Mesenchymal drift: A convergent framework for the hallmarks of aging
  蒙多每日期刊学习系统自动提取。
version: 1.0.0
author: mundo-journal-bot
priority: LOW
auto_activate: MANUAL
category: journal-learnings
source: Cell
published: 2026-05-28
learned: 2026-06-07
---
# Mesenchymal drift: A convergent framework for the hallmarks of aging

**来源**: [Cell](https://www.cell.com/cell/fulltext/S0092-8674(26)00513-1?rss=yes)
**学习日期**: 2026-06-07

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## 摘要

In this issue of Cell, Mao et al. reveal that B cells play an unexpected, immune-independent role in exercise physiology by facilitating multi-organ communication. Secreting TGF-β1, they transcriptionally reprogram hepatic glutamine metabolism via GLS2 and SLC7A5, preserving skeletal muscle glutamate levels, which sustain mitochondrial function, Ca2⁺ signaling, and ATP production, enhancing exercise capacity.

## 关键发现

1. reveal that B cells play an unexpected, immune-independent role in exercise physiology by facilitating multi-organ communication

## 蒙多笔记

> 蒙多从此文中学到：Mesenchymal drift: A convergent framework for the ...
> 此知识已纳入蒙多的学术知识库。

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