Task: Design gene panel for the following purpose:

A human immune oncology gene profiling panel

Plex: 1000 genes with annotation, with genes grouped in major categories

Purpose: the gene panel should have the ability to catalog all cell types, enable immune profiling of the tumor microenvironment and characterize the cell states based on cytokine and cancer signaling pathways. Specifically, the panel should be able to resolve immune cells types, profile key cancer signaling pathways, analyze cell state based on key cytokine profile, understand if a cell is exhausted or not, and distinguish different cancer cell stages based on its expression of different oncogenes or signaling molecules, so that an end user can characterize the tumor microenvironment and explore cancer signaling pathways, etc.
