EvoWeb is an Open Knowledge Network knowledge graph for exploring co-evolving genes and the functional relationships among their protein products. Developed in connection with NIAID data resources and building on the EvoWeaver project, EvoWeb represents weighted protein-protein functional relations reconstructed from prior knowledge encoded in genomic sequences. The graph is designed to help researchers identify hypothetical proteins that may participate in protein complexes, linked biochemical pathway steps, or broader systems of shared evolutionary history. Its registry description highlights twelve coevolutionary signals that quantify how strongly genes appear to have evolved together, extending beyond pairwise protein analysis toward network-level interpretation. The attached entity file indicates that the KG uses lightweight semantic web structures, including SKOS collections and membership relations plus RDFS labels, to organize and describe graph content. Overall, EvoWeb supports comparative genomics, microbial systems biology, and hypothesis generation about gene function, protein interactions, and pathway organization.
