Concordance of differentially expressed genes

OSD-244 · Rodent Research-6 · Space Flight vs Ground Control · ~30 day vs ~60 day timepoints

Concordance of DE genes between ~30 day and ~60 day timepoints Scatter plot of log2 fold change for 322 genes significantly DE in both Space Flight vs Ground Control comparisons. Pearson r = 0.80. 317 concordant, 5 discordant. Concordance of DE genes: SF vs GC, ~30 day vs ~60 day 322 genes significant in both (adj. p ≤ 0.05) · Pearson r = 0.80 Concordant (317) Discordant (5) -6 -6 -4 -4 -2 -2 0 0 2 2 4 4 6 6 Up at both Down at both Down @30, Up @60 Up @30, Down @60 log₂ fold change · ~30 day (SF vs GC) log₂ fold change · ~60 day (SF vs GC) Sim2 Ly6g6c Agt Ceacam19 F10 Hmga1b Clca1 Alox15 F7 Ahsg Prkag3 Gsc Igkv17-121 Hamp Asb5 Prg4 Clec4f Kcnh7 Foxs1 Thbs1 Crb2 Gm24871 Gm33619 2310015K22Rik Gm22488 Gm12238 Gm24451 Rnu12 Snora36b Gm25313 Trbv23 Gm39792 Itm2a Gm26130 Nebl Snora23 Gm22620 Gm25099 Gm39079 Albfm1 Tmem45a2 Gm10319 Mgam

Each point is one of 322 genes that was significantly differentially expressed (adj. p ≤ 0.05) in both the ~30 day and ~60 day SF vs GC comparisons. The dashed gray diagonal is y = x (perfect concordance). Pearson r = 0.80 across the 322 shared genes.