# SPOKE-GeneLab: Studies Investigating Muscles

👤 **User**  
Find all studies that investigated muscles

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🧠 **Assistant**  
I found **12 studies** investigating muscle-related anatomical entities, matched via the UBERON muscle organ hierarchy (UBERON:0001630) with 616 descendant concepts.

| Study ID | Title | Muscle/Anatomy (UBERON) |
|---|---|---|
| OSD-99 | Rodent Research 1 | UBERON:0001386 (extensor digitorum longus) |
| OSD-101 | Rodent Research 1 | UBERON:0001388 (gastrocnemius) |
| OSD-103 | Rodent Research 1 | UBERON:0001377 (soleus) |
| OSD-104 | Rodent Research 1 | UBERON:0001389 (plantaris) |
| OSD-105 | Rodent Research 1 | UBERON:0001385 (tibialis anterior) |
| OSD-326 | Rodent Research-4 | UBERON:0001377 (soleus) |
| OSD-418 | Musculoskeletal Response to a Partial-gravity Analog in Rats | UBERON:0001388 (gastrocnemius) |
| OSD-419 | Rodent Research 1 | UBERON:0001388 (gastrocnemius) |
| OSD-422 | Spacelab Life Sciences 1 (SLS-1) | UBERON:0001388 (gastrocnemius) |
| OSD-576 | Effects of Microgravity on Ocular Vascular Hydrodynamics (80NSSC19K0392) | UBERON:0001385 (tibialis anterior) |
| OSD-665 | Effects of Microgravity on Ocular Vascular Hydrodynamics | UBERON:0001386 (extensor digitorum longus) |
| OSD-666 | Effects of Microgravity on Ocular Vascular Hydrodynamics | UBERON:0001377 (soleus) |

**Key observations:**

- **Rodent Research 1** appears in multiple study entries (OSD-99, 101, 103, 104, 105, 419), each examining a different hindlimb muscle — likely representing distinct assays within the same research program.
- The most commonly studied muscles are the **soleus**, **gastrocnemius**, **tibialis anterior**, and **extensor digitorum longus** — all hindlimb muscles commonly affected by spaceflight-induced atrophy.
- The **"Effects of Microgravity on Ocular Vascular Hydrodynamics"** studies (OSD-576, 665, 666) also examined muscle tissue, likely as a secondary tissue or control.
- **OSD-418** is the most explicitly muscle-focused study, investigating musculoskeletal responses to a partial-gravity analog in rats.

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*Created by [mcp-proto-okn](https://github.com/sbl-sdsc/mcp-proto-okn) 0.5.0 on 2026-02-18*

*Model: claude-sonnet-4-6*
