The spoke-genelab KG complements the spoke-okn (SPOKE Open Knowledge Network) KG and is designed to integrate omics data from NASA’s Open Science Data Repository (OSDR/GeneLab), which hosts results from spaceflight experiments.

The current release includes transcriptional profiling (RNA-Seq, DNA microarray), epigenomic profiling (DNA methylation),and metagenomic profiling (Amplicon sequencing) data from model organisms flown in space or maintained as ground controls. Differential expression. methylation, and abundance signatures are pre-computed to facilitate comparisons between spaceflight and control conditions. Genes from model organisms are systematically mapped to their human orthologs, which allows integration with SPOKE’s rich network of human biology, and therapeutic targets. Cell and tissue types are mapped to the Cell (CL) and Uber Anatomy Ontology (UBERON) ontology, respectively.